AIDS-related lymphoma in Brazil - Histopathology, immunophenotype, and association with Epstein-Barr virus
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/02/1996
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Resumo |
The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several types of immunodeficiency related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, is unknown. Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBER1 biotinylated probe. Twenty cases of AIDS-related lymphoma were classified as non-Hodgkin's lymphoma and four cases were Hodgkin's disease. Eleven non-Hodgkin's lymphomas were classified as diffuse large cell type, five cases were small non-cleaved cell, Burkitt-type, and four cases were large cell immunoblastic non-Hodgkin's lymphoma. Eighteen cases were of B-cell phenotype; one was a T-cell lymphoma, and one was classified as null. Epstein-Barr virus (EBV) was demonstrated in the majority of tumor cells of 11 of 20 (55%) of the cases non-Hodgkin's lymphomas and in 3 of 4 (75%) cases of Hodgkin's disease. AIDS-related lymphomas in Brazil are usually of large cell/immunoblastic type, but Hodgkin's disease is also seen. Both non-Hodgkin's lymphoma and Hodgkin's disease are often associated with EBV infection. The non-Hodgkin's lymphoma is predominantly of B-cell phenotype. |
Formato |
230-237 |
Identificador |
American Journal of Clinical Pathology. Philadelphia: Lippincott-raven Publ, v. 105, n. 2, p. 230-237, 1996. 0002-9173 http://hdl.handle.net/11449/31567 WOS:A1996TU71600017 |
Idioma(s) |
eng |
Publicador |
Lippincott-raven Publ |
Relação |
American Journal of Clinical Pathology |
Direitos |
closedAccess |
Palavras-Chave | #AIDS #HIV #EBV #immunohistochemistry #lymphoma #Hodgkin's disease #in situ hybridization |
Tipo |
info:eu-repo/semantics/article |