CENTRAL ANGIOTENSIN-CONVERTING ENZYME-BLOCKADE AND THIRST
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/09/1993
|
Resumo |
1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g).2. Injection of lisinopril (2 mug/mul) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group).3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied. |
Formato |
999-1007 |
Identificador |
http://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 26, n. 9, p. 999-1007, 1993. 0100-879X http://hdl.handle.net/11449/31477 WOS:A1993LY94100012 |
Idioma(s) |
eng |
Publicador |
Associação Brasileira de Divulgação Científica (ABRADIC) |
Relação |
Brazilian Journal of Medical and Biological Research |
Direitos |
closedAccess |
Palavras-Chave | #WATER INTAKE #DEHYDRATION #HYPOVOLEMIA #ANGIOTENSIN-II #LISINOPRIL #MEDIAL PREOPTIC AREA |
Tipo |
info:eu-repo/semantics/article |