Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/12/2011
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin- 6- C-beta-D-glucopyranoside (1), 7-methoxyluteolin-6-C-beta-D-glucopyranoside (2), 7-methoxyluteolin-8-C-beta-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-beta-D-glucopyranoside (4), and 6- hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxymethyl-1,3,5,6- tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated compounds of the leaves of L. spiralis were assayed against Gram-positive (Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella setubal and Helicobacter pylori) and fungi (the yeasts Candida albicans, C. tropicalis, C. krusei and C. parapsilosis). We observed the best minimum inhibitory concentration values for the methanolic extract against Candida parapsilosis, for the fraction 5 + 6 against Gram-negative bacteria E. coli and P. aeruginosa, and compound 7 against all tested Candida strains. The methanolic extract contents suggest that this species may be a promising source of compounds to produce natural phytomedicines. |
Formato |
10479-10490 |
Identificador |
http://dx.doi.org/10.3390/molecules161210479 Molecules. Basel: Mdpi Ag, v. 16, n. 12, p. 10479-10490, 2011. 1420-3049 http://hdl.handle.net/11449/26371 10.3390/molecules161210479 WOS:000298411200051 WOS000298411200051.pdf |
Idioma(s) |
eng |
Publicador |
Mdpi Ag |
Relação |
Molecules |
Direitos |
openAccess |
Palavras-Chave | #Eriocaulaceae #Leiothrix spiralis #phenolic compounds #antimicrobial activity |
Tipo |
info:eu-repo/semantics/article |