Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity


Autoria(s): de Freitas Araujo, Marcelo Gonzaga; Hilario, Felipe; Nogueira, Leonardo Gorla; Vilegas, Wagner; Santos, Lourdes Campaner dos; Bauab, Tais Maria
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/12/2011

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin- 6- C-beta-D-glucopyranoside (1), 7-methoxyluteolin-6-C-beta-D-glucopyranoside (2), 7-methoxyluteolin-8-C-beta-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-beta-D-glucopyranoside (4), and 6- hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxymethyl-1,3,5,6- tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated compounds of the leaves of L. spiralis were assayed against Gram-positive (Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella setubal and Helicobacter pylori) and fungi (the yeasts Candida albicans, C. tropicalis, C. krusei and C. parapsilosis). We observed the best minimum inhibitory concentration values for the methanolic extract against Candida parapsilosis, for the fraction 5 + 6 against Gram-negative bacteria E. coli and P. aeruginosa, and compound 7 against all tested Candida strains. The methanolic extract contents suggest that this species may be a promising source of compounds to produce natural phytomedicines.

Formato

10479-10490

Identificador

http://dx.doi.org/10.3390/molecules161210479

Molecules. Basel: Mdpi Ag, v. 16, n. 12, p. 10479-10490, 2011.

1420-3049

http://hdl.handle.net/11449/26371

10.3390/molecules161210479

WOS:000298411200051

WOS000298411200051.pdf

Idioma(s)

eng

Publicador

Mdpi Ag

Relação

Molecules

Direitos

openAccess

Palavras-Chave #Eriocaulaceae #Leiothrix spiralis #phenolic compounds #antimicrobial activity
Tipo

info:eu-repo/semantics/article