Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
---|---|
Data(s) |
20/05/2014
20/05/2014
01/01/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 03/02176-7 Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors. |
Formato |
1837-1846 |
Identificador |
http://dx.doi.org/10.1351/PAC-CON-12-01-11 Pure and Applied Chemistry. Res Triangle Pk: Int Union Pure Applied Chemistry, v. 84, n. 9, p. 1837-1846, 2012. 0033-4545 http://hdl.handle.net/11449/26071 10.1351/PAC-CON-12-01-11 WOS:000307817300002 |
Idioma(s) |
eng |
Publicador |
Int Union Pure Applied Chemistry |
Relação |
Pure and Applied Chemistry |
Direitos |
closedAccess |
Palavras-Chave | #Brazilian biomes #drug discovery #medicinal chemistry #natural products #tropical biodiversity |
Tipo |
info:eu-repo/semantics/article |