Hemoglobinas variantes em doadores de sangue do Centro de Hematologia e Hemoterapia do estado do Piauí (Hemopi): conhecendo o perfil epidemiológico para construir a rede de assistência


Autoria(s): Soares, Leonardo F.; Oliveira, Evaldo H.; Lima, Iraildo B.; Silva, José M.; Mota, Jônathas T.; Bonini-Domingos, Claudia R.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/01/2009

Resumo

The most highly prevalent inherited disease in Brazil and in the world, sickle cell anemia, is considered a public health problem. Characterized by homozygosis for the hemoglobin S gene, the individual has a range of signs and symptoms that require careful treatment. The sickle cell trait is characterized by heterozygosis for the hemoglobin S gene, however the carrier does not express the disease. In the current study we aimed at verifying the presence of the sickle cell trait in 1000 blood donors of the Hematology and Hemotherapy Center of the State of Piauí (Hemopi) in the period from October 2007 to April 2008. After analysis by alkaline and acid electrophoresis, positive cases were confirmed by molecular biology. We obtained rates of 3.4% for hemoglobin AS and 5% for hemoglobin AC, with a total frequency of 3.9% in the total of 1,000 blood donors.

Formato

471-472

Identificador

http://dx.doi.org/10.1590/S1516-84842009000600017

Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 31, n. 6, p. 471-472, 2009.

1516-8484

http://hdl.handle.net/11449/21427

10.1590/S1516-84842009000600017

S1516-84842009000600017

S1516-84842009000600017.pdf

Idioma(s)

por

Publicador

Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea

Relação

Revista Brasileira de Hematologia e Hemoterapia

Direitos

openAccess

Palavras-Chave #Hemoglobin S #Blood donors #screening #Laboratory diagnosis #Hb variants
Tipo

info:eu-repo/semantics/article