Evaluation of the antiulcerogenic and analgesic activities of Cordia verbenacea DC. (Boraginaceae)


Autoria(s): Roldao, Erika de Freitas; Witaicenis, Aline; Seito, Leonardo Noboru; Hiruma-Lima, Clélia Akiko; Di Stasi, Luiz Claudio
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

02/09/2008

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ethnopharmacological relevance: Cardia verbenacea is a medicinal plant popularly used in Brazil as antiinflammatory, antiulcer and anti-rheumatic agent without detailed pharmacological and toxicological studies.Aim of the study: The study was aimed to investigate the effects of Cordia verbenacea in antiulcer, analgesic and antioxidant assays, as well as to evaluate its toxic effects and phytochemical profile.Material and methods: Antiulcer activity of plant extract was evaluated using ethanol/HCl, ethanol and piroxican-induced gastric lesions methods. The pH, volume and total acid of gastric juice were determined by pylorus-ligated assay. Analgesic activity was evaluated by writhing, tail-flick and hot-plate tests. Antioxidant activity was determined by in vitro lipoperoxidation assay. Acute toxicity and number of deaths were evaluated by Hippocratic screening.Results: The ethanol leaf extract shows a potent antiulcer activity in the ethanol/HCl and absolute ethanol-induced gastric lesions. The IC50 value of plant extract on the lipid peroxidation was 76.11 mu g/ml. Preliminary phytochemical tests were positive for flavonoids, steroids, saponins, fixed acids, alkaloids and phenols. In the analgesic models the extract did not present any activity.Conclusions: Cordial verbenaceae showed a potent antiulcer activity at the dose of 125 mg/kg and this effect may be associated with an improvement in stomach antioxidant mechanisms. (C) 2008 Elsevier B.V. All rights reserved.

Formato

94-98

Identificador

http://dx.doi.org/10.1016/j.jep.2008.06.001

Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 119, n. 1, p. 94-98, 2008.

0378-8741

http://hdl.handle.net/11449/17824

10.1016/j.jep.2008.06.001

WOS:000259336600014

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Journal of Ethnopharmacology

Direitos

closedAccess

Palavras-Chave #Cordia verbenacea #Boraginaceae #antiulcer #analgesic #antioxidant #acute toxicity
Tipo

info:eu-repo/semantics/article