Osteoconductive Properties of beta-Tricalcium Phosphate Matrix, Polylactic and Polyglycolic Acid Gel, and Calcium Phosphate Cement in Bone Defects
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
30/09/2013
20/05/2014
30/09/2013
20/05/2014
01/09/2012
|
Resumo |
Extensive bone defects in maxillofacial region can be corrected with autogenous grafts; otherwise, the disadvantages of the therapeutics modality take the research for new bone substitutes. The aim of the study was to evaluate and compare the osteoconductive properties of 3 commercial available biomaterials. A total of 30 calvarial defects (5-mm diameter) were randomly divided into 5 treatment groups, with a total of 6 defects per treatment group (n = 6). The treatment groups were as follows: 500 to 1000 Km beta-tricalcium phosphate (beta-TCP), polylactic and polyglycolic acid (PL/PG) gel, calcium phosphate cement, untreated control, and autograft control. The evaluations were based on histomorphometric analysis at 60 postoperative days. The results have shown that beta-TCP and autograft control supported bone formation at 60 postoperative days. beta-Tricalcium phosphate showed the highest amount of mineralized area per total area and statistically significant compared with PL/PG, calcium phosphate cement, and untreated control groups. The PL/PG gel does not have osteoconductive properties and performed similar to empty control. Calcium phosphate cement showed higher number of multinucleated giant cells around the sites of the biomaterial and showed newly formed bone only at the edges of the biomaterial, without bone formation within the biomaterial. The findings presented herein indicate that bone formation reached a maximum level when rat calvarial defects were filled with beta-TCP at 60 postoperative days. Further studies should be conducted with beta-TCP to understand the potential of this biomaterial in bone regeneration. |
Formato |
E430-E433 |
Identificador |
http://dx.doi.org/10.1097/SCS.0b013e31825e4abf Journal of Craniofacial Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 5, p. E430-E433, 2012. 1049-2275 http://hdl.handle.net/11449/15054 10.1097/SCS.0b013e31825e4abf WOS:000309547200023 |
Idioma(s) |
eng |
Publicador |
Lippincott Williams & Wilkins |
Relação |
Journal of Craniofacial Surgery |
Direitos |
closedAccess |
Palavras-Chave | #Osteoconductive properties #beta-tricalcium phosphate #polylactic and polyglycolic acid #calcium phosphate cement #rats #calvarial #bone #biomaterials |
Tipo |
info:eu-repo/semantics/article |