Anemia falciforme: desafios e avanços na busca de novos fármacos
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD. |
Formato |
783-790 |
Identificador |
http://dx.doi.org/10.1590/S0100-40422012000400025 Química Nova. Sociedade Brasileira de Química, v. 35, n. 4, p. 783-790, 2012. 0100-4042 http://hdl.handle.net/11449/8033 10.1590/S0100-40422012000400025 S0100-40422012000400025 WOS:000304226400025 S0100-40422012000400025.pdf |
Idioma(s) |
por |
Publicador |
Sociedade Brasileira de Química |
Relação |
Química Nova |
Direitos |
openAccess |
Palavras-Chave | #Sickle Cell Disease #drug discovery #molecular modification |
Tipo |
info:eu-repo/semantics/article |