Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/06/2009
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 02/10893-8 Processo FAPESP: 02/07306-3 To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. |
Formato |
953-955 |
Identificador |
http://dx.doi.org/10.1128/CVI.00071-09 Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009. 1556-6811 http://hdl.handle.net/11449/7262 10.1128/CVI.00071-09 WOS:000266638900025 WOS000266638900025.pdf |
Idioma(s) |
eng |
Publicador |
Amer Soc Microbiology |
Relação |
Clinical and Vaccine Immunology |
Direitos |
closedAccess |
Tipo |
info:eu-repo/semantics/article |