Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella


Autoria(s): Zalewski, Cynthia A.; Passero, Luiz Felipe D.; Melo, Alexis S. R. B.; Corbett, Carlos Eduardo P.; Laurenti, Marcia D.; Toyama, Marcos H.; Toyama, Daniela O.; Romoff, Paulete; Favero, Oriana A.; Lago, Joao Henrique G.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/06/2011

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Context: Species of Baccharis exhibit antibiotic, antiseptic, and wound-healing properties, and have been used in the traditional medicine of South America for the treatment of inflammation, headaches, diabetes, and hepatobiliary disorders.Objective: To investigate the anti-inflammatory activity of organic phases from EtOH extract of the aerial parts of Baccharis uncinella DC (Asteraceae).Materials and methods: The crude EtOH extract from the aerial parts of B. uncinella was subjected to partition procedures and the corresponding CH(2)Cl(2) and EtOAc phases were subjected to several chromatographic separation procedures. Thus, these phases and their purified compounds were assayed for evaluation of anti-inflammatory activity.Results: The CH(2)Cl(2) phase from EtOH extract from B. uncinella contained two triterpenoids (oleanolic and ursolic acids) and one flavonoid (pectolinaringenin), whereas the respective EtOAc phase showed to be composed mainly by two phenylpropanoid derivatives (caffeic and ferulic acids). The CH(2)Cl(2) and EtOAc phases as well as their isolated compounds exhibited anti-inflammatory effects against inflammatory reactions induced by phospholipase A2 (from Crotalus durissus terrificus venom) and by carrageenan.Discussion and conclusion: The results suggested that the components obtained from partition phases of EtOH extract of B. uncinella could represent lead molecules for the development of anti-inflammatory agents. Additionally, the results confirmed the use of Baccharis genus in the traditional medicine of South America for the treatment of inflammation and other heath disorders. To date, the present work describes for the first time the anti-inflammatory effects of compounds isolated from B. uncinella.

Formato

602-607

Identificador

http://dx.doi.org/10.3109/13880209.2010.537828

Pharmaceutical Biology. London: Informa Healthcare, v. 49, n. 6, p. 602-607, 2011.

1388-0209

http://hdl.handle.net/11449/377

10.3109/13880209.2010.537828

WOS:000290404200008

Idioma(s)

eng

Publicador

Informa Healthcare

Relação

Pharmaceutical Biology

Direitos

closedAccess

Palavras-Chave #Secretory phospholipase A2 (sPLA2) #anti-inflammatory #triterpenes #phenolic compounds
Tipo

info:eu-repo/semantics/article