Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years
Data(s) |
01/05/2015
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Resumo |
BACKGROUND: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. METHODS: Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. RESULTS: Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably. CONCLUSIONS: CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30076615/carter-pseudomonasaeruginosa-2015.pdf http://www.dx.doi.org/10.1016/j.jcf.2014.12.007 |
Direitos |
2015, Elsevier |
Palavras-Chave | #Cystic fibrosis #Eradication #Genotyping #Infection #Pseudomonas aeruginosa #ACFBAL Study Investigators #Science & Technology #Life Sciences & Biomedicine #Respiratory System #LAVAGE-DIRECTED THERAPY #CHRONIC LUNG INFECTION #YOUNG-CHILDREN #BRONCHOALVEOLAR LAVAGE #OROPHARYNGEAL CULTURES #ERADICATION THERAPY #DIAGNOSTIC-TOOL #STRAINS #INFANTS #COLONIZATION |
Tipo |
Journal Article |