Molecular regulation of survivin targeted nano-therapy in advanced prostate cancer
Contribuinte(s) |
Kanwar (nee Kaur), Rupinder Kanwar Jagat |
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Data(s) |
01/03/2015
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Resumo |
The increasing complexities of prostate cancer disease progression necessitates more stable and less toxic therapeutic strategies. The current study demonstrated for the first time, the survivin targeted anti-cancer therapeutic activity of the bio-molecular drugs such as SurR9-C84A and bovine lactoferrin in inducing prostate cancer specific apoptosis. Moreover, improved therapeutic efficacy was conferred to these bio-molecules either by their encapsulation in stem cell targeted bio-compatible nanoparticles, or by the synthesis of protein-cytotoxic drug conjugates. This study also highlighted the role played by miRNAs in the regulation of iron metabolism and apoptosis, mediated by the selective activation of p53 and PTEN pathways. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Deakin Univeristy, Faculty of Health, School of Medicine |
Relação |
http://dro.deakin.edu.au/eserv/DU:30079289/shankaranarayanan-agreement-2015.pdf http://dro.deakin.edu.au/eserv/DU:30079289/shankaranarayanan-molecular-2015.pdf |
Direitos |
The author |
Palavras-Chave | #prostate cancer #therapeutics |
Tipo |
Thesis |