Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness
Data(s) |
30/03/2015
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Resumo |
This study aimed to investigate the association of obsessive-compulsive symptoms with clinical and neurocognitive features in patients with schizophrenia. This study enrolled 163 people with schizophrenia who were receiving risperidone monotherapy. Comorbid obsessive-compulsive symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale, and subjects with a score≥10 constituted the obsessive-compulsive symptom group (n=30, 18.4%). The learning index was significantly higher in patients with obsessive-compulsive symptoms than in those without such symptoms after adjusting for age, stage (early and chronic), duration of illness, and CDSS score. However, there was no significant interaction between obsessive-compulsive symptoms and stage of illness. Scores on Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia, and Beck Depression Inventory were significantly higher in the obsessive-compulsive symptom group. In addition, the Subjective Well-being under Neuroleptic Treatment score was significantly lower in the obsessive-compulsive symptom group. In conclusion, comorbid obsessive-compulsive symptoms in patients with schizophrenia were associated with a higher learning ability without a significant interaction with stage of illness. However, schizophrenia patients with obsessive-compulsive symptoms had more severe psychotic and depressive symptoms and poorer quality of life. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30073843/berk-associationof-2015.pdf http://dro.deakin.edu.au/eserv/DU:30073843/berk-associationsof-inpress-2015.pdf http://www.dx.doi.org/10.1016/j.psychres.2015.01.021 |
Direitos |
2015, Elsevier |
Palavras-Chave | #Cognition #Comorbidity #Depression #Obsessive-compulsive symptoms #Quality of life #Schizophrenia |
Tipo |
Journal Article |