Molecular insights and oligonucleotide based targeted gene therapy against cancer
| Contribuinte(s) |
Kanwar Jagat Subramanian, Krishnakumar Kanwar (nee Kaur), Rupinder |
|---|---|
| Data(s) |
01/10/2014
|
| Resumo |
The thesis helps to unravel the function of T lymphoma invasion and metastasis protein (TIAM1) and nucleolin, a nucleolar protein in retinoblastoma tumorigenesis. Aptamer based targeted imaging; drug and gene delivery to retinoblastoma and epithelial cancer cells was attained. The work work finally opened up avenues for cancer stem cell targeting using aptamers, imaging of cancer cells using novel bio-orthogonal agent and use of aptamer for blocking the miRNA-17-92 cluster maturation. |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
Deakin University, Faculty of Health, School of Medicine |
| Relação |
http://dro.deakin.edu.au/eserv/DU:30073699/subramanian-agreement-2015.pdf http://dro.deakin.edu.au/eserv/DU:30073699/subramanian-molecular-2015A.pdf |
| Direitos |
The Author. All Rights Reserved |
| Palavras-Chave | #retinoblastoma #aptamer #epithelial cancer cells #cancer markers #cancer stem cell #RB #CSC |
| Tipo |
Thesis |
