miRNA modulation of SOCS1 using an influenza A virus delivery system
Data(s) |
01/09/2014
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Resumo |
Difficulties associated with efficient delivery and targeting of miRNAs to cells is hampering the real world application of miRNA technology. This study utilized an influenza A-based delivery system to express miR-155 in order to knockdown SOCS1 mRNA. Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-β cytokines. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Society for General Microbiology |
Relação |
http://dro.deakin.edu.au/eserv/DU:30071593/izzard-mirnamodulationof-2014.pdf http://www.dx.doi.org/10.1099/vir.0.063834-0 http://www.ncbi.nlm.nih.gov/pubmed/24876306 |
Direitos |
2014, Society for General Microbiology |
Palavras-Chave | #Science & Technology #Life Sciences & Biomedicine #Biotechnology & Applied Microbiology #Virology #IMMUNE-RESPONSE #EXPRESSION #RNAS #SUPPRESSOR #PROTEIN #CELLS |
Tipo |
Journal Article |