Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature
Data(s) |
01/12/2015
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Resumo |
Autism is a disorder of unknown etiology. There are few FDA approved medications for treating autism. Co-occurring autism and epilepsy is common, and glutamate antagonists improve some symptoms of autism. Ceftriaxone, a beta-lactam antibiotic, increases the expression of the glutamate transporter 1 which decreases extracellular glutamate levels. It is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. This case report of a child with autism and epilepsy suggests a decrease in seizures after taking cefixime |
Identificador | |
Idioma(s) |
eng |
Publicador |
Iranian Child Neurology Society |
Relação |
http://dro.deakin.edu.au/eserv/DU:30070215/berk-betalactam-2015.pdf |
Direitos |
2015, Iranian Child Neurology Society |
Palavras-Chave | #Antibiotic #Cefixime #Glutamate #Inflammation #Therapy #Transporter |
Tipo |
Journal Article |