Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Data(s) |
01/07/2014
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Resumo |
We investigated the association between undercarboxylated osteocalcin (ucOC) and lower-limb muscle strength in women over the age of 70years. The study also aims to confirm the association between bone turnover markers and heel ultrasound measures. A post-hoc analysis using data collected as part of a randomized placebo-controlled trial of vitamin D supplementation. An immunoassay was used to quantify total OC (tOC), with hydroxyapatite pre-treatment for ucOC. We determined associations of absolute and relative (ucOC/tOC; ucOC%) measures of ucOC with lower-limb muscle strength, heel ultrasound measures of speed of sound (SOS) and broadband ultrasound attenuation (BUA), bone turnover markers (BTMs; P1NP and CTx) and the acute phase protein alpha-1-antichymotrypsin (α-ACT). ucOC%, but not absolute ucOC concentration, was positively associated with hip flexor, hip abductor and quadriceps muscle strength (all p<0.05). ucOC% was negatively associated with α-ACT (β-coefficient=-0.24, p=0.02). tOC was positively associated with both P1NP and CTx (p<0.001). For each per unit increase in tOC (μg/L) there was a corresponding lower BUA, SOS and SI (β-coefficient = -0.28; -0.23 and -0.23, respectively; all p<0.04). In conclusion, ucOC% is positively associated with muscle strength and negatively associated with α-ACT. These data support a role for ucOC in musculoskeletal interactions in humans. Whilst tOC is associated with bone health, ucOC% and ucOC may also be linked to falls and fracture risk by influencing muscle function. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30069700/stuart-undercarboloxylatedosteoc-2014.pdf http://www.dx.doi.org/10.1016/j.bone.2014.03.008 http://www.ncbi.nlm.nih.gov/pubmed/24662619 |
Direitos |
2014, Elsevier |
Palavras-Chave | #Bone remodelling #Muscle strength #Older-adults #Osteocalcin #Undercarboxylated osteocalcin #Science & Technology #Life Sciences & Biomedicine #Endocrinology & Metabolism #POSTMENOPAUSAL WOMEN #INSULIN SENSITIVITY #ENERGY-METABOLISM #SKELETAL-MUSCLE #OSTEOPOROSIS #ALENDRONATE #EXERCISE #TRIALS #MASS |
Tipo |
Journal Article |