Randomized controlled trial examining the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells
Data(s) |
01/05/2014
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Resumo |
The present randomized, placebo-controlled, double-blind, parallel-groups clinical trial examined the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells. Healthy adult humans (n = 160) were randomized to receive 6 g of fish oil, 6 g of fish oil plus a multivitamin, 3 g of fish oil plus a multivitamin or a placebo daily for 16 weeks. Treatment with 6 g of fish oil, with or without a daily multivitamin, led to higher eicosapentaenoic acid (EPA) composition at endpoint. Docosahexaenoic acid (DHA) composition was unchanged following treatment. The long chain LC n-3 PUFA index was only higher, compared to placebo, in the group receiving the combination of 6 g of fish oil and the multivitamin. Analysis by gender revealed that all treatments increased EPA incorporation in females while, in males, EPA was only significantly increased by the 6 g fish oil multivitamin combination. There was considerable individual variability in the red blood cell incorporation of EPA and DHA at endpoint. Gender contributed to a large proportion of this variability with females generally showing higher LC n-3 PUFA composition at endpoint. In conclusion, the incorporation of LC n-3 PUFA into red blood cells was influenced by dosage, the concurrent intake of vitamin/minerals and gender. |
Identificador | |
Idioma(s) |
eng |
Publicador |
MDPI |
Relação |
http://dro.deakin.edu.au/eserv/DU:30067522/sinclair-randomized-2014.pdf http://www.dx.doi.org/10.3390/nu6051956 http://www.ncbi.nlm.nih.gov/pubmed/24830830 |
Direitos |
2014, MDPI |
Palavras-Chave | #Controlled trial (RCT) #Diet #Fatty acid #Fish oils #Multivitamins #n-3 #Randomized #Science & Technology #Life Sciences & Biomedicine #Nutrition & Dietetics #ALZHEIMERS-DISEASE #ERYTHROCYTE-MEMBRANES #COGNITIVE PERFORMANCE #FOLIC-ACID #OMEGA-3-FATTY-ACIDS #SERUM #PLASMA #HEALTH #ADULTS #RATS |
Tipo |
Journal Article |