Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells.
Data(s) |
01/03/2014
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Resumo |
Plumbagin (PLB) has shown anti-cancer activity but the mechanism is unclear. This study has found that PLB has a potent pro-apoptotic and pro-autophagic effect on A549 and H23 cells. PLB arrests cells in G2/M phase, and increases the intracellular level of reactive oxygen species in both cell lines. PLB dose-dependently induces autophagy through inhibition of PI3K/Akt/mTOR pathway as indicated by reduced phosphorylation of Akt and mTOR. Inhibition or induction of autophagy enhances PLB-induced apoptosis. There is crosstalk between PLB-induced apoptosis and autophagy. These findings indicate that PLB initiates both apoptosis and autophagy in NSCLC cells through coordinated pathways. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier Ireland |
Relação |
http://dro.deakin.edu.au/eserv/DU:30067326/duan-plumbagininduces-2014.pdf http://www.dx.doi.org/10.1016/j.canlet.2013.11.001 http://www.ncbi.nlm.nih.gov/pubmed/24280585 |
Direitos |
2014, Elsevier |
Palavras-Chave | #Apoptosis #Autophagy #Non-small-cell lung cancer #PI3K/Akt/mTOR #Plumbagin #Science & Technology #Life Sciences & Biomedicine #Oncology #NF-KAPPA-B #CYTOCHROME-C #CYCLE ARREST #IN-VITRO #SIGNALING PATHWAY #BONE METASTASIS #P53 #BREAST #PHOSPHORYLATION #EXPRESSION |
Tipo |
Journal Article |