Escitalopram efficacy in depression a cross-ethnicity examination of the serotonin transporter promoter polymorphism
Data(s) |
01/10/2014
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Resumo |
Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Sage Publications |
Relação |
http://dro.deakin.edu.au/eserv/DU:30065249/singh-escitalopramefficacy-2014.pdf |
Direitos |
2014, Sage Publications |
Palavras-Chave | #antidepressant #genotype #pharmacogenetic #efficacy |
Tipo |
Journal Article |