Oral baclofen in children with cerebral palsy : a double-blind cross-over pilot study
Data(s) |
01/01/2006
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Resumo |
Aim: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. Methods: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. Results: Fifteen children with mean age 7.4 years (SD = 2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13) = 4.5, P = 0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. Conclusion: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell Publishing |
Relação |
http://dro.deakin.edu.au/eserv/DU:30052316/hall-oralbaclofen-2006.pdf http://dx.doi.org/10.1111/j.1440-1754.2006.00957.x |
Palavras-Chave | #baclofen #cerebral palsy #clinical trial #oral administration #spasticity |
Tipo |
Journal Article |