Origins of adaptive immunity
Data(s) |
01/01/2011
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Resumo |
Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole-genome duplications. Through a close examination of the key molecules and molecular processes underpinning adaptive immunity, this review suggests a less-extreme model, in which adaptive immunity emerged as part of longer evolutionary journey. Clearly, whole-genome duplications provided additional raw genetic materials that were vital to the emergence of adaptive immunity, but a variety of other genetic events were also required to generate some of the key molecules, whereas others were preexisting and simply co-opted into adaptive immunity.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Begell House Inc. |
Relação |
http://dro.deakin.edu.au/eserv/DU:30042859/ward-originsof-evid-2011.pdf http://dro.deakin.edu.au/eserv/DU:30042859/ward-originsof-post-2011.pdf |
Palavras-Chave | #adaptive immunity #evolution #BCR #TCR #MHC #RAG #cytokine signaling #transcription factors |
Tipo |
Journal Article |