A general approach to N-heterocyclic scaffolds using domino Heck-aza-Michael reactions
Data(s) |
01/01/2011
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Resumo |
Palladium-catalyzed domino Heck–aza-Michael reactions for the synthesis of a series of C1-substituted tetrahydro-β-carbolines, tetrahydroisoquinolines and isoindolines are described. The domino process involves the initial intermolecular Heck reaction of an aryl bromide with an electron deficient alkene, followed by an intramolecular aza-Michael reaction to form the new N-heterocycle in high yield. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Royal Society of Chemistry |
Relação |
http://dro.deakin.edu.au/eserv/DU:30040415/priebbenow-ageneralapproach-2011.pdf http://dx.doi.org/10.1039/c0ob00835d |
Direitos |
2011, The Royal Society of Chemistry |
Tipo |
Journal Article |