Effects of N-acetylcysteine on substance use in bipolar disorder : a randomized placebo controlled clinical trial
Data(s) |
01/10/2009
|
---|---|
Resumo |
<b>Objective: </b>To evaluate the effect of N-acetylcysteine (NAC) on substance use in a double-blind, placebo-controlled trial of NAC in bipolar disorder. It is hypothesised that NAC will be superior to placebo for reducing scores on the Clinical Global Impressions scale for Substance Use (CGI-SU).<br /><b><br />Methods:</b> Participants were randomised to 6-months of treatment with 2 g/day NAC (n = 38) or placebo (n = 37). Substance use was assessed at baseline using the Habits instrument. Change in substance use was assessed at regular study visits using the CGI-SU.<br /><br /><b>Results:</b> Amongst the 75 participants 78.7% drank alcohol (any frequency), 45.3% smoked tobacco and 92% consumer caffeine. Other substances were used by fewer than six participants. Caffeine use was significantly lower for NAC-treated participants compared with placebo at week 2 of treatment but not at other study visits.<br /><br /><b>Conclusion:</b> NAC appeared to have little effect on substance use in this population. A larger study on a substance using population will be necessary to determine if NAC may be a useful treatment for substance use.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley Blackwell |
Relação |
http://dro.deakin.edu.au/eserv/DU:30035563/dodd-effectsofnacetylcysteine-2009.pdf http://dx.doi.org/10.1111/j.1601-5215.2009.00415.x |
Direitos |
2009, John Wiley & Sons |
Palavras-Chave | #alcohol #bipolar disorder #caffeine #clinical trial #N-acetyl cysteine #smoking #substance use |
Tipo |
Journal Article |