Tobacco smoking as a risk factor for major depressive disorder : a population-based study


Autoria(s): Pasco, Julie A.; Williams, Lana J.; Jacka, Felice N.; Ng, Felicity; Henry, Margaret J.; Nicholson, Geoffrey C.; Kotowicz, Mark A.; Berk, Michael
Data(s)

01/10/2008

Resumo

<b>Background :</b> Smoking is disproportionately prevalent among people with psychiatric illness. <br /><br /><b>Aims : </b>To investigate smoking as a risk factor for major depressive disorder. <br /><br /><b>Method :</b> A population-based sample of women was studied using case–control and retrospective cohort study designs. Exposure to smoking was self-reported, and major depressive disorder diagnosed using the Structured Clinical Interview for DSM–IV–TR (SCID–I/NP). <br /><br /><b>Results :</b> Among 165 people with major depressive disorder and 806 controls, smoking was associated with increased odds for major depressive disorder (age-adjusted odds ratio (OR)=1.46, 95% CI 1.03–2.07). Compared with non-smokers, odds for major depressive disorder more than doubled for heavy smokers (>20 cigarettes/day). Among 671 women with no history of major depressive disorder at baseline, 13 of 87 smokers and 38 of 584 non-smokers developed de novo major depressive disorder during a decade of follow-up. Smoking increased major depressive disorder risk by 93% (hazard ratio (HR)=1.93, 95% CI 1.02–3.69); this was not explained by physical activity or alcohol consumption. <br /><br /><b>Conclusions : </b>Evidence from cross-sectional and longitudinal data suggests that smoking increases the risk of major depressive disorder in women.

Identificador

http://hdl.handle.net/10536/DRO/DU:30033177

Idioma(s)

eng

Publicador

Royal College of Psychiatrists

Relação

http://dro.deakin.edu.au/eserv/DU:30033177/jacka-tobaccosmoking-2008.pdf

http://dx.doi.org/10.1192/bjp.bp.107.046706

Direitos

2008, Royal College of Psychiatrists

Tipo

Journal Article