Exercise and MEF2–HDAC interactions.
Data(s) |
01/10/2007
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Resumo |
Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
N R C Research Press |
Relação |
http://dro.deakin.edu.au/eserv/DU:30025017/mcgee-exerciseand-2007.pdf http://search.ebscohost.com/login.aspx?direct=true |
Direitos |
2007, NRC Canada |
Tipo |
Journal Article |