Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity: a report from the Australian Rheumatology Association Database
Data(s) |
01/01/2009
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Resumo |
<b>Aims</b>: To compare the baseline characteristics of a population-based cohort of patients with ankylosing spondylitis (AS) commencing biological therapy to the reported characteristics of bDMARD randomised controlled trials (RCTs) participants. <br /><b>Methods</b>: Descriptive analysis of AS participants in the Australian Rheumatology Association Database (ARAD) who were commencing bDMARD therapy. <br /><b>Results</b>: Up to December 2008, 389 patients with AS were enrolled in ARAD. 354 (91.0%) had taken bDMARDs at some time, and 198 (55.9%) completed their entry questionnaire prior to or within 6 months of commencing bDMARDs. 131 (66.1%) had at least one comorbid condition, and 24 (6.8%) had a previous malignancy (15 nonmelanoma skin, 4 melanoma, 2 prostate, 1 breast, cervix, and bowel). Compared with RCT participants, ARAD participants were older, had longer disease duration and higher baseline disease activity. <br /><b>Conclusions</b>: AS patients commencing bDMARDs in routine care are significantly different to RCT participants and have significant baseline comorbidities.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Hindawi Publishing Corp. |
Relação |
http://dro.deakin.edu.au/eserv/DU:30024913/murphy-ankylosingspondylitis-2009.pdf http://dx.doi.org/10.1155/2009/268569 https://symplectic.its.deakin.edu.au/viewobject.html?cid=1&id=49322 |
Direitos |
2009, The Authors |
Tipo |
Journal Article |