Immunostimulatory principles from Chlorella pyrenoidosa – part 1 : isolation and biological assessment in vitro
Data(s) |
10/01/2007
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Resumo |
Our proprietary preparation obtained by extraction of <i>Chlorella pyrenoidosa</i> cells, ONC-107 (Respondin™), was recently found to selectively boost antibody response to the influenza vaccine in a human clinical trial. Respondin™ is a potent stimulator of mouse B cell proliferation and an activator of macrophages. Bioactivity-guided resolution concluded that Respondin™ is composed of a mixture of immunostimulatory principles of different chemical nature. A combination of size exclusion, anion exchange and hydrophobic interaction chromatography revealed that the bulk of the immunostimulatory activity resides in polysaccharide/protein complexes with molecular masses larger than 100 kDa that are composed primarily of galactose, rhamnose and arabinose.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
G. Fischer |
Relação |
http://dro.deakin.edu.au/eserv/DU:30019501/barrow-immunostimulatoryprinciples-2007.pdf http://dx.doi.org/10.1016/j.phymed.2005.09.002 |
Direitos |
2005, Elsevier |
Palavras-Chave | #Chlorella extract #bioassay-guided fractionation #immunostimulatory #B cells #macrophages |
Tipo |
Journal Article |