Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata)
Data(s) |
01/07/2008
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Resumo |
We measured aerobic metabolism during cold exposure and exercise performance (run duration and oxygen consumption while running at 1 m s<sup>−1</sup>) in the fat-tailed dunnart <i>Sminthopsis crassicaudata</i>, a dasyurid marsupial, before and after ingestion of 30 mg kg<sup>−1</sup> of fenitrothion, an organophosphate (OP) pesticide. Running endurance of OP-exposed animals was less than half that of control animals over the first 3 days after dosing and 55% of control animal endurance on day 5 post-dose. Despite these declines, peak metabolic rate at this running speed (9.3 times basal metabolic rate; BMR) was unaffected by OP exposure. Peak metabolic rate (PMR) and cumulative oxygen consumption during a 1-h exposure to conditions equivalent to −20 °C did not differ between OP-treated and control dunnarts, with PMR averaging 11 times BMR. We conclude that fenitrothion-induced exercise fatigue is not due to limitations in oxygen or substrate delivery to muscle or in their uptake <i>per se</i>, but more likely relates to decreased ability to sustain high-frequency neuromuscular function. The persistence of locomotor impairment following OP exposure in otherwise asymptomatic animals emphasizes the importance of using performance-based measures when characterising sublethal effects of pesticide exposure in an ecological context.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30018647/astheimer-fenitrothionanorganiphosphate-2008.pdf http://dx.doi.org/10.1016/j.chemosphere.2008.04.054 |
Direitos |
2008, Elsevier |
Palavras-Chave | #marsupial #organophosphate #oxygen consumption #running endurance thermogenesis #fenitrothion |
Tipo |
Journal Article |