Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution
Data(s) |
01/01/2008
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Resumo |
The mammary gland undergoes a sophisticated programme of developmental changes during pregnancy/lactation. However, little is known about processes involving initiation of apoptosis at involution following weaning. We used fur seals as models to study the molecular process of involution as these animals display a unique mammary gland phenotype. Fur seals have long lactation periods whereby mothers cycle between secreting copious quantities of milk for 2 to 3 days suckling pups on land, with trips to sea alone to forage for up to 23 days during which time mammary glands remain active without initiating apoptosis/involution.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
BioMed Central |
Relação |
http://dro.deakin.edu.au/eserv/DU:30017999/lefevre-lackof-2008.pdf http://dx.doi.org/10.1186/1741-7007-6-48 |
Direitos |
2008, BioMed Central |
Tipo |
Journal Article |