Effects of purified herbal extract of Saliva miltiorrhiza on ischemic rat myocardium after acute myocardial infarction
Data(s) |
29/04/2005
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Resumo |
In the current study, we compared purified <i>Salvia miltiorrhiza</i> extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage.<br /><br />After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30009149/n20062206.pdf http://dx.doi.org/10.1016/j.lfs.2004.11.016 |
Direitos |
2005, Elsevier Inc. |
Palavras-Chave | #purified Salvia miltiorrhiza extract (PSME) #myocardial infarction #Salvia miltiorrhiza #antioxidant #infarct size #Ramipril |
Tipo |
Journal Article |