Effects of Salvia miltiorrhiza after acute myocardial infarction in rats
Contribuinte(s) |
Tan, Benny K-H Bay, Boon-Huat Zhu, Yi-Zhun |
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Data(s) |
01/01/2004
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Resumo |
Acute myocardial infarction (M!) is the commonest cause of death in the developed countries, and it is on the rise in developing countries. Ramipril is a well-knownAngiotensin-converting enzyme (ACE) inhibitorwhich inhibits conversion ofinactive angiotensin I to active angiotensin II. Experimental studies have shown thatACE inhibitors administered chronicallybefore acuteMImight limitmyocardial infarct size, improve cardiac function and prevent cardiac hypertrophy [1, 2]. The Chinese herb, <i>Salvia miltiorrhiza</i> (SM), has been widely and successfully usedmainly for anginapectoris,MI and stroke [3]. Compared to ramipril, however, there is very limited biochemical information availableto demonstrate themechanismsofSMs<br />cardio-protective effects. This study thus investigates the possible<br />biochemical and molecularmechanisms ofsuch effects ofSMin Wistar rats in comparison with those oframipril.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
World Scientific |
Relação |
http://dro.deakin.edu.au/eserv/DU:30008346/n20070280.pdf |
Direitos |
2004, World Scientific |
Tipo |
Book Chapter |