Inheritance beyond plain heritability : variance-controlling genes in Arabidopsis thaliana


Autoria(s): Shen, Xia; Pettersson, Mats; Rönnegård, Lars; Carlborg, Örjan
Data(s)

2012

Resumo

The phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here, we reanalyze a publicly available Arabidopsis thaliana dataset [1] and show that genetic variance heterogeneity appears to be as common as normal additive effects on a genomewide scale. The study also develops theory to estimate the contributions of variance differences between genotypes to the phenotypic variance, and this is used to show that individual loci can explain more than 20% of the phenotypic variance. Two well-studied systems, cellular control of molybdenum level by the ion-transporter MOT1 and flowering-time regulation by the FRI-FLC expression network, and a novel association for Leaf serration are used to illustrate the contribution of major individual loci, expression pathways, and gene-by-environment interactions to the genetic variance heterogeneity.

Formato

application/pdf

Identificador

http://urn.kb.se/resolve?urn=urn:nbn:se:du-10538

doi:10.1371/journal.pgen.1002839

PMID 22876191

ISI:000308529300006

Idioma(s)

eng

Publicador

Högskolan Dalarna, Statistik

Högskolan Dalarna, Statistik

Relação

PLOS Genetics, 1553-7390, 2012, 8:8,

Direitos

info:eu-repo/semantics/openAccess

Tipo

Article in journal

info:eu-repo/semantics/article

text

Palavras-Chave #Genetics #Genetik