Stability and compatibility study on enalapril maleate using thermoanalytical techniques
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2008
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| Resumo |
This paper demonstrates the application of thermal analysis in compatibility and stability studies between it ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed (luring the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO3 increases the thermal stability of the drug. This Study Supports the importance of using thermoanalytical methods in the development of pharmaceuticals. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) |
| Identificador |
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v.93, n.3, p.881-886, 2008 1388-6150 http://producao.usp.br/handle/BDPI/31274 10.1007/s10973-007-8187-4 |
| Idioma(s) |
eng |
| Publicador |
SPRINGER |
| Relação |
Journal of Thermal Analysis and Calorimetry |
| Direitos |
restrictedAccess Copyright SPRINGER |
| Palavras-Chave | #compatibility #DSC #enalapril maleate #stability #TG #thermal stabilization #DRUG-EXCIPIENT COMPATIBILITY #IR MICROSCOPIC SYSTEM #PHYSICOCHEMICAL TECHNIQUES #DECOMPOSITION #CYCLIZATION #POLYMORPHS #KINETICS #DSC #Chemistry, Analytical #Chemistry, Physical |
| Tipo |
article original article publishedVersion |
