Antioxidant effect of functionalized alkyl-organotellurides: a study in vitro


Autoria(s): GAY, Bibiana M.; LUCHESE, Cristiane; NOGUEIRA, Cristina W.; WENDLER, P.; MACEDO, Alexandra; SANTOS, Alcindo A. Dos
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2010

Resumo

We evaluated the in vitro antioxidant effect of alkyl-organotellurides A-D on lipid peroxidation and protein carbonylation in rat liver homogenates. The thiol oxidase and thiol peroxidase-like activities of compounds were investigated. delta-Aminolevulinic acid dehydratase (delta-ALA-D) activity was determined in rat liver homogenates. Compounds A-D protected against lipid peroxidation induced by Fe(2+)/EDTA and sodium nitroprusside (SNP). According to the confidence limits of the IC(50) values of compounds A-D, the IC(50) values for organotellurides followed the order: C (0.30 mu M) <= B (0.40 mu M) < D (0.68 mu M) < A (2.90 mu M), for Fe(2+)/EDTA, and B (0.21 mu M) <= C (0.33 mu M) < D (0.43 mu M) < A (1.21 mu M) for SNP-induced lipid peroxidation. Compounds A-D reduced protein carbonyl content to control levels. The results demonstrated an inverse correlation between thiol oxidase and delta-ALA-D activities. This study supports an antioxidant effect of organotellurides A-D on rat liver.

UFSM (FIPE)

UFSM (FIPE)

FAPERGS

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)

CAPES

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

FAPESP

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

CNPq

Identificador

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.25, n.4, p.467-475, 2010

1475-6366

http://producao.usp.br/handle/BDPI/31053

10.3109/14756360903257892

http://dx.doi.org/10.3109/14756360903257892

Idioma(s)

eng

Publicador

TAYLOR & FRANCIS LTD

Relação

Journal of Enzyme Inhibition and Medicinal Chemistry

Direitos

closedAccess

Copyright TAYLOR & FRANCIS LTD

Palavras-Chave #Functionalized alkyl-organotellurides #antioxidant #tellurium #liver lipid peroxidation #DELTA-AMINOLEVULINATE DEHYDRATASE #DIPHENYL DISELENIDE #OXIDATIVE STRESS #THIOREDOXIN REDUCTASE #LIPID-PEROXIDATION #DITELLURIDE #BRAIN #ACID #MICE #DISEASE #Biochemistry & Molecular Biology #Chemistry, Medicinal
Tipo

article

original article

publishedVersion