Antioxidant effect of functionalized alkyl-organotellurides: a study in vitro
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2010
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Resumo |
We evaluated the in vitro antioxidant effect of alkyl-organotellurides A-D on lipid peroxidation and protein carbonylation in rat liver homogenates. The thiol oxidase and thiol peroxidase-like activities of compounds were investigated. delta-Aminolevulinic acid dehydratase (delta-ALA-D) activity was determined in rat liver homogenates. Compounds A-D protected against lipid peroxidation induced by Fe(2+)/EDTA and sodium nitroprusside (SNP). According to the confidence limits of the IC(50) values of compounds A-D, the IC(50) values for organotellurides followed the order: C (0.30 mu M) <= B (0.40 mu M) < D (0.68 mu M) < A (2.90 mu M), for Fe(2+)/EDTA, and B (0.21 mu M) <= C (0.33 mu M) < D (0.43 mu M) < A (1.21 mu M) for SNP-induced lipid peroxidation. Compounds A-D reduced protein carbonyl content to control levels. The results demonstrated an inverse correlation between thiol oxidase and delta-ALA-D activities. This study supports an antioxidant effect of organotellurides A-D on rat liver. UFSM (FIPE) UFSM (FIPE) FAPERGS Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) FAPESP Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq |
Identificador |
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.25, n.4, p.467-475, 2010 1475-6366 http://producao.usp.br/handle/BDPI/31053 10.3109/14756360903257892 |
Idioma(s) |
eng |
Publicador |
TAYLOR & FRANCIS LTD |
Relação |
Journal of Enzyme Inhibition and Medicinal Chemistry |
Direitos |
closedAccess Copyright TAYLOR & FRANCIS LTD |
Palavras-Chave | #Functionalized alkyl-organotellurides #antioxidant #tellurium #liver lipid peroxidation #DELTA-AMINOLEVULINATE DEHYDRATASE #DIPHENYL DISELENIDE #OXIDATIVE STRESS #THIOREDOXIN REDUCTASE #LIPID-PEROXIDATION #DITELLURIDE #BRAIN #ACID #MICE #DISEASE #Biochemistry & Molecular Biology #Chemistry, Medicinal |
Tipo |
article original article publishedVersion |