Reactive nitrogen intermediate susceptibility of Mycobacterium tuberculosis genotypes in an urban setting


Autoria(s): INUMARU, V. T. G.; NOGUEIRA, P. A.; BUTUEM, I. V.; RILEY, L. W.; FERRAZOLI, L.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

BACKGROUND: Mycobacterium tuberculosis genotypes resistant to reactive nitrogen intermediates (RNI) predominate in certain urban communities, suggesting that this phenotype influences disease transmission. OBJECTIVE: To compare different M. tuberculosis genotypes for resistance to RNI generated in vitro. DESIGN: We genotyped 420 M. tuberculosis isolates from a neighborhood in Sao Paulo, Brazil, and analyzed them for susceptibility to RNI generated in acidified sodium nitrite (ASN) solution. RESULTS: Seventy-one (43%) of 167 recent-infection strains and 68 (43%) of 158 endogenous infection strains showed moderate- to high-level ASN resistance. CONCLUSION: ASN resistance of M. tuberculosis is not necessarily a determining factor for enhanced transmission.

Conselho Nacional cle Desenvolvimento Cientifico e Tecnologico (CNPq)

NIH Fogarty International Center[TW006563]

Identificador

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.13, n.5, p.665-668, 2009

1027-3719

http://producao.usp.br/handle/BDPI/26712

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000265424900024&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)

Relação

International Journal of Tuberculosis and Lung Disease

Direitos

restrictedAccess

Copyright INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)

Palavras-Chave #Mycobacterium tuberculosis #nitric oxide #RNI #RFLP #ASN #STRAIN #TRANSMISSION #COMMUNITY #Infectious Diseases #Respiratory System
Tipo

article

original article

publishedVersion