Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros


Autoria(s): Vaiyapuri, Sakthivel; Wagstaff, Simon C; Watson, Kimberly Ann; Harrison, R. A.; Gibbins, Jonathan Martin; Hutchinson, E. Gail
Data(s)

10/08/2010

Resumo

This study describes the discovery and characterisation of a novel aminopeptidase A from the venom of B. g. rhinoceros and highlights its potential biological importance. Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. Furthermore, it could have additional effects on the biological functions of other host proteins by cleaving their N-terminal amino acids. This study points towards the importance of complete analysis of individual components of snake venom in order to develop effective therapies for snake bites.

Formato

text

Identificador

http://centaur.reading.ac.uk/17906/1/SVT_Plos.pdf

Vaiyapuri, S. <http://centaur.reading.ac.uk/view/creators/90000475.html>, Wagstaff, S. C., Watson, K. A. <http://centaur.reading.ac.uk/view/creators/90000363.html>, Harrison, R. A., Gibbins, J. M. <http://centaur.reading.ac.uk/view/creators/90000133.html> and Hutchinson, E. G. (2010) Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Neglected Tropical Diseases, 4 (8). e796. ISSN 1935-2735 doi: 10.1371/journal.pntd.0000796 <http://dx.doi.org/10.1371/journal.pntd.0000796>

Idioma(s)

en

Publicador

Public Library of Science

Relação

http://centaur.reading.ac.uk/17906/

creatorInternal Vaiyapuri, Sakthivel

creatorInternal Watson, Kimberly Ann

creatorInternal Gibbins, Jonathan Martin

10.1371/journal.pntd.0000796

Tipo

Article

PeerReviewed