Cellular signals of cisplatin ototoxicity
| Data(s) |
01/01/2011
|
|---|---|
| Resumo |
Three separate theories of inhibiting cisplatin-induced apoptosis were investigated utilizing different cellular mechanisms. Specifically, the copper transport cycle, TRPV1, and the JNK pathway were inhibited and immunohistochemistry was performed to determine levels of apoptosis. All three resulted in statistically significant effects; increasing CuSO4 levels resulted in increased apoptosis, and inhibiting TRPV1 |
| Formato |
application/pdf |
| Identificador |
http://digitalcommons.wustl.edu/pacs_capstones/616 http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=1635&context=pacs_capstones |
| Idioma(s) |
English |
| Publicador |
Digital Commons@Becker |
| Fonte |
Independent Studies and Capstones |
| Palavras-Chave | #Medicine and Health Sciences |
| Tipo |
text |
