Prevalencia de enfermedad celiaca en Latinoamérica: revisión sistemática de la literatura y meta-análisis


Autoria(s): Parra-Medina, Rafael; Molano-Gonzalez, Nicolas; Rojas-Villarraga, Adriana; Anaya, Juan-Manuel
Contribuinte(s)

Anaya, Juan-Manuel

Data(s)

13/10/2014

Resumo

Introducción: La enfermedad celiaca (EC) es una enfermedad autoinmune (EA) intestinal desencadenada por la ingesta de gluten. Por la falta de información de la presencia de EC en Latinoamérica (LA), nosotros investigamos la prevalencia de la enfermedad en esta región utilizando una revisión sistemática de la literatura y un meta-análisis. Métodos y resultados: Este trabajo fue realizado en dos fases: La primera, fue un estudio de corte transversal de 300 individuos Colombianos. La segunda, fue una revisión sistemática y una meta-regresión siguiendo las guías PRSIMA. Nuestros resultados ponen de manifiesto una falta de anti-transglutaminasa tisular (tTG) e IgA anti-endomisio (EMA) en la población Colombiana. En la revisión sistemática, 72 artículos cumplían con los criterios de selección, la prevalencia estimada de EC en LA fue de 0,46% a 0,64%, mientras que la prevalencia en familiares de primer grado fue de 5,5 a 5,6%, y en los pacientes con diabetes mellitus tipo 1 fue de 4,6% a 8,7% Conclusión: Nuestro estudio muestra que la prevalencia de EC en pacientes sanos de LA es similar a la notificada en la población europea.

Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Because information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the word through a systematic review and meta-analysis Methods and Findings: This report describes a two-phase study. First, a cross-sectional analysis from 300 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were made following the PRISMA guidelines. Our results disclose a lack of anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA) autoantibody in Colombians. In the systematic review, after 72 studies that met the selection criteria were considered, the estimated prevalence of CD in LA was 0,46% to 0,64%, whereas the prevalence of CD was 5,5 to 5,6% in first degree relatives of CD patients and 4,6% to 8,7% in type 1 diabetes mellitus patients. Conclusions: Our study shows that prevalence of CD in healthy patients from LA is similar to the prevalence reported in the European population.

Formato

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Identificador

http://repository.urosario.edu.co/handle/10336/9004

Idioma(s)

spa

Publicador

Facultad de medicina

Direitos

info:eu-repo/semantics/openAccess

Fonte

instname:Universidad del Rosario

reponame:Repositorio Institucional EdocUR

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TEME

Palavras-Chave #616.079 #Enfermedad celiaca #Inmunología #Medicina #Gluten #Celiac disease; Latin America; Meta-analysis; Meta-regression
Tipo

info:eu-repo/semantics/bachelorThesis

info:eu-repo/semantics/acceptedVersion