Genetic diversity and selection in three plasmodium vivax merozoite surface protein 7 (pvmsp-7) genes in a colombian population
Data(s) |
25/09/2012
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Resumo |
A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine. |
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application/pdf |
Identificador | |
Idioma(s) |
eng |
Relação |
PLOS ONE ISSN: 1932-6203 V. 7 N. 9 Sep. 25, 2012 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045962 |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR ISSN:ISSN:ISSN:1932-6203 |
Palavras-Chave | #616.9362 #Malaria #Genoma #Enfermedades infecciosas #Genética #CAENORHABDITIS-ELEGANS GENOME #AMINO-ACID SITES #MALARIA PARASITE #POSITIVE SELECTION #INTRAGENIC RECOMBINATION #STATISTICAL TESTS #DEATH EVOLUTION #MSP7 FAMILY #FALCIPARUM #COMPLEX |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |