The multiple autoimmune syndromes. A clue for the autoimmune tautology


Autoria(s): Anaya, Juan-Manuel; Castiblanco, John; Rojas-Villarraga, Adriana
Data(s)

01/12/2012

Resumo

The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sjögren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology). © Springer Science+Business Media, LLC 2012.

Formato

application/pdf

Identificador

http://repository.urosario.edu.co/handle/10336/8835

Idioma(s)

eng

Relação

Clinical Reviews in Allergy and Immunology ISSN: 10800549 V. 43 N. 3 Dic, 2012

http://download.springer.com.ez.urosario.edu.co/static/pdf/694/art%253A10.1007%252Fs12016-012-8317-z.pdf?auth66=1401459721_a9bcbda61d2bf958e29280528fcd218b&ext=.pdf

Direitos

info:eu-repo/semantics/openAccess

Fonte

instname:Universidad del Rosario

reponame:Repositorio Institucional EdocUR

ISSN:ISSN:ISSN:10800549

Palavras-Chave #614.5993 #Inmunoglobulina #Inmunología #Enfermedades autoinmunes #antinuclear antibody #cardiolipin antibody #double stranded DNA antibody #immunoglobulin G antibody #La antibody #ribonucleoprotein antibody #Ro antibody #Sm antibody #thyroglobulin antibody #thyroid peroxidase antibody
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/acceptedVersion