Experiencia en nefrectomía: serie de casos de cuatro años


Autoria(s): Soto Morales, Claudio Giovanni
Contribuinte(s)

Salgado Tovar, Javier Mauricio

Data(s)

20/01/2014

31/12/1969

Resumo

Introducción: Las indicaciones por las cuales un paciente requiere una nefrectomía son múltiples: las neoplasias, la hidronefrosis y la exclusión funcional son las principales. En manos expertas la nefrectomía es un procedimiento seguro, especialmente porque en la actualidad el abordaje por excelencia es realizar una técnica mínimamente invasiva con conservación de nefronas. Se presenta el análisis de la experiencia en Mederi, Hospital Universitario Mayor en esta intervención. Metodología: Se realizó una serie de casos de pacientes llevados a nefrectomía entre mayo de 2008 y mayo de 2012. Se incluyeron la totalidad de los casos. Resultados: Se analizaron 72 registros, 49 mujeres y 25 hombres; 13 de ellas fueron laparoscópicas. La edad promedio fue de 58,6 años. El tiempo medio operatorio fue 169,23 minutos (118-220 minutos). El sangrado operatorio promedio fue de 680,63 ml (IC95%: 2,83-1358 ml). El tiempo de hospitalización promedio fue de 4,88 días IC95%. La mayoría de los pacientes se distribuyeron en estadios medios de la enfermedad tumoral, con poco compromiso ganglionar y metástasis; el diagnóstico histológico y estadio dominante fueron el carcinoma de células renales grado 3 de Fuhrman respectivamente. Se reportan 13 casos de compromiso de la capsula de Gerota y 11 con compromiso del hilio. Discusión: La experiencia en nefrectomía de la institución es muy positiva por el bajo número de mortalidad y complicaciones. En cuanto a la técnica, es importante promover la técnica laparoscópica

Introduction: The indications for a patient to require a nephrectomy are multiples, neoplasms, hydronephrosis and functional exclusion are the main causes. In experienced hands nephrectomy is a safe procedure, especially because nowadays the main approach is to perform a minimally invasive technique with nephron sparing. Analysis of the experience in Mederi is shown in this study. Methods A case series of patients who underwent nephrectomy between May 2008 and May 2012 was performed. All cases were included. Results 72 records, 49 women and 25 men were analyzed, 13 of which were laparoscopic. The average age was 58.6 years. The average operative time was 169.23 minutes (118- 220minutes). The mean operative blood loss was 680.63 ml. The mean hospital stay was 4.88 days, most patients were distributed in the middle stages of tumor disease, with little nodal involvement and metastasis, histological diagnosis and were the dominant stage renal cell carcinoma Fuhrman stage 3 respectively, 13 cases of Gerota 's capsule commitment and 11 cases with renal hilum commitment. The concordance between the imaging diagnosis (clinical) and intraoperative finding was moderate (κ0.46). Discussion Nephrectomy experience of the institution is very positive because of the low number of complications and mortality. As for the technique, it is important to promote the laparoscopic one.

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Identificador

http://repository.urosario.edu.co/handle/10336/4887

Idioma(s)

spa

Publicador

Facultad de Medicina

Direitos

info:eu-repo/semantics/embargoedAccess

Fonte

reponame:Repositorio Institucional EdocUR

instname:Universidad del Rosario

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Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur. J. Cancer [Internet]. 2010 Mar [cited 2013 Aug 8];464:765–81. Disponible en:: http://www.ncbi.nlm.nih.gov/pubmed/20116997

Varela R, Donoso W, Corredor H. Experiencia de nefrectomía radical en el Instituto Nacional de Cancerología. Bogotá, Colombia. Serie de casos. Urol. Colomb. [Internet]. 2010 [cited 2013 Oct 5];XIX2:39–44. Disponible en:: http://dialnet.unirioja.es/servlet/articulo?codigo=3423529

Thyavihally Y. Management of renal cell carcinoma with solitary metastasis. World J Urol [Internet]. 2005 [cited 2013 Aug 28];9:1–9. Disponible en:: http://www.biomedcentral.com/1477-7819/3/48

Beisland C, Medby PC, Beisland HO. Presumed radically treated renal cell carcinoma--recurrence of the disease and prognostic factors for subsequent survival. Scand. J. Urol. Nephrol. [Internet]. 2004 Jan;384:299–305. Disponible en:: http://www.ncbi.nlm.nih.gov/pubmed/15669589

Shekarriz B, Upadhyay J, Shekarriz H, de Assis Mendes Goes F, Bianco FJ, Tiguert R, et al. Comparison of costs and complications of radical and partial nephrectomy for treatment of localized renal cell carcinoma. Urology [Internet]. 2002 Feb [cited 2013 Sep 12];592:211–5. Disponible en:: http://www.ncbi.nlm.nih.gov/pubmed/11834387

Cairns P. Renal cell carcinoma. Cancer Biomark. [Internet]. 2010 Jan [cited 2013 Sep 12]; 91 - 6: 461 – 73. www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3308682&tool=pmcentrez&rendertype=abstract

Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J. Urol. [Internet]. 2006 Dec [cited 2013 Dec 17];176(6 Pt 1):2353–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17085101

Stafford HS, Saltzstein SL, Shimasaki S, Sanders C, Downs TM, Sadler GR. Racial/ethnic and gender disparities in renal cell carcinoma incidence and survival. J. Urol. [Internet]. 2008 May [cited 2013 Dec 17];179(5):1704–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2677163&tool=pmcentrez&rendertype=abstract

Kümmerlin IPED, ten Kate FJW, Wijkstra H, de la Rosette JJMCH, Laguna MP. Changes in the stage and surgical management of renal tumours during 1995-2005: an analysis of the Dutch national histopathology registry. BJU Int. [Internet]. 2008 Oct [cited 2013 Dec 17];102(8):946–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18564136

Konnak JW, Grossman HB. Renal cell carcinoma as an incidental finding. J. Urol. [Internet]. 1985 Dec [cited 2013 Dec 17];134(6):1094–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4057398

Thompson IM, Peek M. Improvement in survival of patients with renal cell carcinoma--the role of the serendipitously detected tumor. J. Urol. [Internet]. 1988 Sep [cited 2013 Dec 17];140(3):487–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3411657

Kessler O, Mukamel E, Hadar H, Gillon G, Konechezky M, Servadio C. Effect of improved diagnosis of renal cell carcinoma on the course of the disease. J. Surg. Oncol. [Internet]. 1994 Nov [cited 2013 Dec 17];57(3):201–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7967611

Parsons JK, Schoenberg MS, Carter HB. Incidental renal tumors: casting doubt on the efficacy of early intervention. Urology [Internet]. 2001 Jun [cited 2013 Dec 17];57(6):1013–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11377295

Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer [Internet]. 2008 Jul 1 [cited 2013 Dec 17];113(1):78–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18491376

Hock LM, Lynch J, Balaji KC. Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J. Urol. [Internet]. 2002 Jan [cited 2013 Dec 17];167(1):57–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11743275

Wallen EM, Pruthi RS, Joyce GF, Wise M. Kidney cancer. J. Urol. [Internet]. 2007 Jun [cited 2013 Dec 17];177(6):2006–18; discussion 2018–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17509280

Decastro GJ, McKiernan JM. Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol. Clin. North Am. [Internet]. 2008 Nov [cited 2013 Dec 17];35(4):581–92; vi. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18992612

Sanders PW. Pathogenesis and treatment of myeloma kidney. J. Lab. Clin. Med. [Internet]. 1994 Oct [cited 2013 Dec 17];124(4):484–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7930873

Sufrin G, Chasan S, Golio A, Murphy GP. Paraneoplastic and serologic syndromes of renal adenocarcinoma. Semin. Urol. [Internet]. 1989 Aug [cited 2013 Dec 17];7(3):158–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2690260

Gold PJ, Fefer A, Thompson JA. Paraneoplastic manifestations of renal cell carcinoma. Semin. Urol. Oncol. [Internet]. 1996 Nov [cited 2013 Dec 17];14(4):216–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8946620

Moein MR, Dehghani VO. Hypertension: a rare presentation of renal cell carcinoma. J. Urol. [Internet]. 2000 Dec [cited 2013 Dec 17];164(6):2019. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11061907

Wiesener MS, Seyfarth M, Warnecke C, Jürgensen JS, Rosenberger C, Morgan N V, et al. Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma. Blood [Internet]. 2002 May 15 [cited 2013 Dec 17];99(10):3562–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11986208

Kamra D, Boselli J, Sloane BB, Gladstone DE. Renal cell carcinoma induced Coombs negative autoimmune hemolytic anemia and severe thrombocytopenia responsive to nephrectomy. J. Urol. [Internet]. 2002 Mar [cited 2013 Dec 17];167(3):1395. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11832746

Hagel C, Stavrou D, Hansen HC. Paraneoplastic frontal lobe disorder and ataxia in renal cell carcinoma. Neuropathol. Appl. Neurobiol. [Internet]. 2005 Feb [cited 2013 Dec 17];31(1):97–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15634236

Costanzi S, Zoli A, Ferraro PM, Danza FM, Ferraccioli GF. A paraneoplastic retroperitoneal fibrosis resistant to corticosteroids treated with tamoxifen. Clin. Nephrol. [Internet]. 2008 Aug [cited 2013 Dec 17];70(2):172–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18793535

Moazzam M, Ather MH, Hussainy AS. Leiomyosarcoma presenting as a spontaneously ruptured renal tumor-case report. BMC Urol. [Internet]. 2002 Nov 19 [cited 2013 Dec 17];2:13. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138801&tool=pmcentrez&rendertype=abstract

Elias AN. New-onset insulinopenic diabetes mellitus in a patient with an incidentally discovered renal cell carcinoma. Am. J. Med. [Internet]. 2005 Sep [cited 2013 Dec 17];118(9):1047–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16164894

Khatri V, Asensio J. Operative surgery manual [Internet]. 2003 [cited 2013 Oct 8]. Disponible en:: http://www.lavoisier.fr/livre/notice.asp?ouvrage=1517546

Batata M, Grabstald H. Upper urinary tract urothelial tumors. Urol Clin North Am. 1976;3:79–86.

Herr H. Long-term results of BCG therapy: concern about upper tract tumors. Semin Urol Oncol. 1998;16:13–6.

Lane B, Campbell S, Poggio E, Al. E. Renal function assessment in the era of chronic kidney disease: renewed emphasis on renal function centered patient care. J Urol. 2009;182:4335–444.

Rini B, Campbell S, Escudier B. Renal cell carcinoma. Lancet. 2009;373:1119–32.

Fuhrman S, Lasky L, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;7:655–63.

Dall’Oglio MF, Arap MA, Antunes AA, Cury J, Leite KR, Srougi M. Impact of clinicopathological parameters in patients treated for renal cell carcinoma. J. Urol. [Internet]. 2007 May [cited 2013 Aug 28];1775:1687–91. Disponible en:: http://www.ncbi.nlm.nih.gov/pubmed/17437783

Sánchez Zalabardo D, Arocena García-Tapia J, Regojo Balboa JM, Fernández Montero JM, López Ferrandis J, Rosell Costa D, et al. Factores pronóstico en carcinoma renal pT3. Actas Urol. Esp. [Internet]. Elsevier España S. L.; 2003 Jan [cited 2013 Oct 28];271:26–32. Disponible en:: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062003000100006&lng=es&nrm=iso&tlng=e

Lacombe M. Renal arteriovenous fistula following nephrectomy. Urology [Internet]. 1985 Jan [cited 2014 Jan 22];25(1):13–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3966275

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Palavras-Chave #NEFRECTOMÍA #nephrectomy
Tipo

info:eu-repo/semantics/bachelorThesis

info:eu-repo/semantics/submittedVersion