Alterations in brainstem a2 adrenoreceptor activity in pyridoxine-deficient rat model of hypertension


Autoria(s): Viswanathan,M; Paulose,C S; Lal,K J; Sharma,S K; Dakshinamurti,K
Data(s)

04/08/2008

04/08/2008

27/11/1989

Resumo

Moderate pyridoxine deficiency in adult male Sprague-Dawley rats results in significant hypertension, associated with a general sympathetic stimulation , including an increase in the turnover of norepinephrine in the heart. Treatment of these rats with pyridoxine reversed blood pressure to normal within 24 h. Treatment of pyridoxine-deficient rats with clonidine or x-methyl dihydroxyphenylalanine (x-methyl DOPA) also reduced the blood pressure of these animals to normal . There was also a significant increase in the Bma, of high and low affinity [3H]p-amino-clonidine binding to crude synaptosomal membrane preparations of the brain stem of deficient rats indicating chronic underexposure of)(, adrenoreceptors to endogenous norepinephrin.

Identificador

http://dyuthi.cusat.ac.in/purl/592

Idioma(s)

en

Publicador

Department of Biotechnology

Palavras-Chave #Hypertension #Pyridoxine deficiency #Sympathetic activity #Brainstem #x, Adrenoreceptor
Tipo

Working Paper