The relationship between body mass index and breast cancer recurrence/progression and breast cancer-specific death


Autoria(s): Tosevski, Cedomir
Contribuinte(s)

Applied Health Sciences Program

Data(s)

08/03/2011

08/03/2011

08/03/2011

Resumo

The aim of this study was to describe the nonlinear association between body mass index (BMI) and breast cancer outcomes and to determine whether BMI improves prediction of outcomes. A cohort of906 breast cancer patients diagnosed at Henry Ford Health System, Detroit (1985-1990) were studied. The median follow-up was 10 years. Multivariate logistic regression was used to model breast cancer recurrence/progression and breast cancer-specific death. Restricted cubic splines were used to model nonlinear effects. Receiver operator characteristic areas under the curves (ROC AUC) were used to evaluate prediction. BMI was nonlinearly associated with recurrence/progression and death (p= 0.0230 and 0.0101). Probability of outcomes increased with increase or decrease ofBMI away from 25. BMI splines were suggestive of improved prediction of death. The ROC AUCs for nested models with and without BMI were 0.8424 and 0.8331 (p= 0.08). I f causally associated, modifying patients BMI towards 25 may improve outcomes.

Identificador

http://hdl.handle.net/10464/3187

Idioma(s)

eng

Publicador

Brock University

Palavras-Chave #Obesity -- Health aspects #Breast -- Cancer
Tipo

Electronic Thesis or Dissertation