BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Data(s) |
2000
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Resumo |
The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population. |
Identificador |
https://serval.unil.ch/notice/serval:BIB_FD7EEF16556C info:pmid:10880534 https://serval.unil.ch/resource/serval:BIB_FD7EEF16556C.P001/REF http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_FD7EEF16556C1 urn:nbn:ch:serval-BIB_FD7EEF16556C1 |
Idioma(s) |
eng |
Fonte |
Journal of Experimental Medicine1921129-135 |
Palavras-Chave | #Animals; B-Cell Activating Factor; B-Cell Maturation Antigen; B-Lymphocytes/immunology; Cell Line; Cell Survival; Homeostasis; Humans; Immunoglobulin G/immunology; Immunoglobulin kappa-Chains/genetics; Immunoglobulin kappa-Chains/immunology; Lymphocyte Activation; Membrane Proteins/genetics; Membrane Proteins/immunology; Mice; Mice, Inbred BALB C; Palatine Tonsil/immunology; Receptors, Tumor Necrosis Factor/genetics; Receptors, Tumor Necrosis Factor/immunology; Recombinant Proteins/immunology; Spleen/immunology; Transfection; Tumor Necrosis Factor-alpha |
Tipo |
info:eu-repo/semantics/article article |
Formato |
application/pdf |
Direitos |
info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer |