Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism
Data(s) |
2008
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Resumo |
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity. |
Identificador |
https://serval.unil.ch/notice/serval:BIB_5F148A65F68F info:pmid:17387702 pmid:17387702 doi:10.1002/pbc.21176 isiid:000251410400034 |
Idioma(s) |
eng |
Fonte |
Pediatric Blood & Cancer501154-156 |
Palavras-Chave | #Antimetabolites, Antineoplastic; Child; Female; Homozygote; Humans; Kidney Failure, Acute; Lymphoma, T-Cell; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic |
Tipo |
info:eu-repo/semantics/article article |