Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.


Autoria(s): Lubin Jay H.; Gaudet Mia M.; Olshan Andrew F.; Kelsey Karl; Boffetta Paolo; Brennan Paul; Castellsague Xavier; Chen Chu; Curado Maria Paula; Dal Maso Luigino; Daudt Alexander W.; Fabianova Eleonora; Fernandez Leticia; Wünsch-Filho Victor; Franceschi Silvia; Herrero Rolando; Koifman Sergio; La Vecchia Carlo; Lazarus Philip; Levi Fabio; Lissowska Jolanta; Mates Ioan Nicolae; Matos Elena; McClean Michael; Menezes Ana; Morgenstern Hal; Muscat Joshua; Eluf-Neto Jose; Purdue Mark P.; Rudnai Peter; Schwartz Stephen M.; Shangina Oxana; Sturgis Erich M.; Szeszenia-Dabrowska Neonilia; Talamini Renato; Wei Qingyi; Winn Deborah; Zhang Zuo-Feng; Hashibe Mia; Hayes Richard B.
Data(s)

2010

Resumo

Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.

Identificador

https://serval.unil.ch/?id=serval:BIB_08D1F4AE3116

isbn:1476-6256[electronic], 0002-9262[linking]

pmid:20494999

doi:10.1093/aje/kwq088

isiid:000278435700001

Idioma(s)

en

Direitos

info:eu-repo/semantics/openAccess

Fonte

American Journal of Epidemiology, vol. 171, no. 12, pp. 1250-1261

Palavras-Chave #Alcohol Drinking/adverse effects; Body Mass Index; Case-Control Studies; Humans; Laryngeal Neoplasms/etiology; Mouth Neoplasms/etiology; Odds Ratio; Pharyngeal Neoplasms/etiology; Risk Factors; Smoking/adverse effects
Tipo

info:eu-repo/semantics/article

article