Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.


Autoria(s): Bessa J.; Jegerlehner A.; Hinton H.J.; Pumpens P.; Saudan P.; Schneider P.; Bachmann M.F.
Data(s)

2009

Resumo

The mechanisms regulating systemic and mucosal IgA responses in the respiratory tract are incompletely understood. Using virus-like particles loaded with single-stranded RNA as a ligand for TLR7, we found that systemic vs mucosal IgA responses in mice were differently regulated. Systemic IgA responses following s.c. immunization were T cell independent and did not require TACI or TGFbeta, whereas mucosal IgA production was dependent on Th cells, TACI, and TGFbeta. Strikingly, both responses required TLR7 signaling, but systemic IgA depended upon TLR7 signaling directly to B cells whereas mucosal IgA required TLR7 signaling to lung dendritic cells and alveolar macrophages. Our data show that IgA switching is controlled differently according to the cell type receiving TLR signals. This knowledge should facilitate the development of IgA-inducing vaccines.

Identificador

https://serval.unil.ch/?id=serval:BIB_07CE97F4A6F0

isbn:1550-6606[electronic], 0022-1767[linking]

pmid:19710454

doi:10.4049/jimmunol.0804004

isiid:000270179700030

Idioma(s)

en

Fonte

Journal of Immunology, vol. 183, no. 6, pp. 3788-3799

Palavras-Chave #Animals; Dendritic Cells/immunology; Immunoglobulin A/biosynthesis; Lung/immunology; Macrophages, Alveolar/immunology; Membrane Glycoproteins; Mice; Mice, Knockout; Mucous Membrane/immunology; RNA/immunology; T-Lymphocytes, Helper-Inducer; Toll-Like Receptor 7; Transforming Growth Factor beta; Transmembrane Activator and CAML Interactor Protein
Tipo

info:eu-repo/semantics/article

article