Synthesis of new enzyme stabilisers inspired by compatible solutes of hyperthermophilic microorganisms

Dissertation presented to obtain the Ph.D degree in Engineering Sciences and Technology.

In response to osmotic or heat stress, marine hyperthermophiles (thriving optimally at or above 80ºC) accumulate ionic compatible solutes such as α-Dmannosyl- D-glycerate (MG). It has been proposed that these hypersolutes stabilise intracellular components, such as proteins and enzymes, allowing them to withstand high growth temperatures.(...)