Inheritance of histone H3 variants across mitotic cell divisions

Dissertation presented to obtain the Ph.D degree in Molecular Biology.

Cell proliferation and differentiation into distinct cell types during development requires the preservation of cellular phenotypes during cell divisions. How the cell maintains its identity and how cells with the same genetic information display different heritable phenotypes or gene expression profiles are fundamental questions in biology. The mitotic and/or meiotic inheritance of changes in gene expression that are not due to changes in DNA sequences is known as epigenetic inheritance.(...)